need so clarification.

[Pelion]

Unless Villains can see your cards, you're making connections that just don't make sense.

While this is probably true, blockers have a fairly large effect on the EV of 4bet bluffing as well. e.g. AQ is likely to be a much better 4bet bluff hand than 67s (in spots where we can't value call/raise it) because it makes it less likely villain has AA/QQ/AK etc. Likewise Ax, Kx type hands are usually going to be better than middle card hands.

Also, based on admittedly small sample size, I feel like I get more folds when I insta 4bet AA than when I think for a little and 4bet bluff A2s.

[acg123]

While this is probably true, blockers have a fairly large effect on the EV of 4bet bluffing as well. e.g. AQ is likely to be a much better 4bet bluff hand than 67s (in spots where we can't value call/raise it) because it makes it less likely villain has AA/QQ/AK etc. Likewise Ax, Kx type hands are usually going to be better than middle card hands.

Also, based on admittedly small sample size, I feel like I get more folds when I insta 4bet AA than when I think for a little and 4bet bluff A2s.

lol very true I don't think I realize things like that sometimes or don't take them into consideration after debating for 6-7 seconds whether to 4bet where if I have AA it takes 0 seconds to know im 4betting.