In general, as you move up, predictable play and lines work less and less. Villains are more sophisticated at reading hands/ranges and more creative with their betting lines. As a response, the standard nut-farming that crushes micro-stakes becomes more and more exploited.

That said, the differences between 2NL and 10NL are pretty subtle. The standard villain doesn't change much until 25NL. The switch up to 25NL is the first "tough" jump, as it's the lowest stakes that a competent player can earn a living wage, albeit meager.

With this in mind, I wouldn't change much in moving from 2NL to 5NL, as the villains are still mostly recreational fish. There will be more people like you who are trying to crush the game, so identify them and identify the fish and play each villain accordingly.

You'll still see "OMG WTF limp-call pre-flop on a 3-bet pot 3-handed from UTG then min-donk/fold on J65r flop" all too often.