Fold both. Not sure why you find these problematic, you've no reason to feel villain's range is weak in either of these last two so just fold. I like the give up in hand 2. without more info that this guys totally mental in hand 1, you're looking at Ax the vast majority of the time.

Unfortunately there is no magic way to win hands where our opponent's range kills us

Iso larger in both of these preflop.