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Yes.
Against nondescript blinds, and a passive limper who folds as little as 40% to your isolation, and as little as 50% to cbets, it is profitable to isolate with any two cards on the button. In this spot, against such a player, I refrain from isolating only for game flow reasons, or if I have one of the least valuable hands. Your T4o, etc. Otherwise, I ball on them.
Folded to me in BB, with one limper, I'm as loose-aggressive, if not more so. What you loose from being OOP I feel is made up for by the superior odds from already having a blind in, and the guarantee of being heads up, should a flop happen.
I think such an attitude is especially important in 6-max, where picking up these tiny pots is vital.
If you've been asking yourself where it is the thinking lag player finds the extra 5-10 percent of hands to play, this is one of the places, in my opinion. Limpers play bad, and you want to play lots of heads up raised pots in position with initiative against them.
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