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Long winded reply, and please anyone with more experience than me, shoot this full of holes 
I've started to use a variation on the Sklansky hand rankings to determine my raising strategy pre-flop. Basically the groups are as follows:
A: AA, AKs, KKs
B: AK, QQ
C: JJ, TT
D: AQs, AQ, AJs, 99, 88
E: AJ, ATs, KQs, 77, 66, 55
F: AT, KQ, KJs, QJs, 44, 33, 22
What I've tended to do is the following - assuming everyone has limped before me (6-max only, no idea how this would change for full ring):
Early position: Raise with groups A,B,C,D; Call a raise with B,C; Re-raise with A
Mid position: Raise with A,B,C,D,E; Call with C, re-raise with A,B
Late: Raise with A-F; Call with C,D; re-raise A,B
I've found that my profitability has gone up significantly with this, from 33% win after seeing flop, to 55%.
This might be due to other factors as well (sharpening up on reads etc.) but the groupings and playing more strictly have helped.
Now obviously this should be adjusted dependant on table and villians, but for a starting point it works for me.
Anyone here who thinks this needs tweaking?
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