In a recent game w/ my friends one guy flopped a nut straight and was all-in againt 3 guys, 2 of which ended up w/ a full house.

If you (against 2 opponents) have a straight, w/ 2 cards of same suit on the board, and you are fairly sure one person has a flush draw and the other a set, is it worth it to risk all your money, either in a cash game or tournament?