I'm not real sure how to ask my question in a way that makes sense but i'm gonna give it a shot. This question/thought came up in a poker discussion last night.

We were discussing if/when is it ok to go "against the odds" or basically when the math or pot odds say FOLD but your read says RAISE. I guess my question is, over the long run, can a person get good enough at reading opponents that; 1)they can play -ev hands and 2)overcome wrong pot odds; and still be profitable at poker.

If your answer is YES, how can you develop these skills.....