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Personally, I dont bother defending the blinds, If it is raised from the CO or BTN, then you are OOP the whole hand (if they do decide to call) by giving up your blind you lose a tiny bit of EV, its only 1BB, also its much better to be the blind stealer than the blind defender. If you do decide to defend your blind by reraising with a marginal hand, say BTN raises to 4BB, and you hold Q10s - an OK hand, but your not gonna win a big pot with it OOP, especially in a heads up pot with a BTN who likely has rags and wont pay you off if you hit unless your beat. you then can either reraise, to 14xBB (IMO 12xBB would be too small, you want to try to end the hand now as youll be OOP) than thats 14xBB to win 5BB, or you can fold and lose 1BB. I usually fold all but the best hands when the button raises, due to the above factors, I'll even throw 22-55 as the implied odds are just not there when facing a button raiser, and I dont want to be playing a big pot OOP with these small PP's unless i hit a set, and its very unlikely ill get paid off if i do.
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