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One important thing to realise is that in heads-up play the small blind is in position post-flop and the big blind is out of position. (This is different from blind versus blind in a normal game where the small blind is out of position throughout the hand and the big blind is in position.)
As a result:
Opening very wide from SB/BTN - yes.
Calling wide from BB - not as much. You can, of course, call, taking into account you're often going to be ahead of your opponent's wide range, but in general, being out of position is a strong incentive to either 3-bet or fold.
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