That's a pretty general question so I'm going to narrow it down.

Let's say MP2-Button makes a PF raise. You have no reads. You are in the SB or BB. I want to limit the hands you might have to the following: QJo, QJs, KQo, KQs, AJo, AQo. These are all tough hands for me to play and I always consider folding them to a prior raise.

Looking at poker tracker, KQo, QJo, AQo and AJo are all in the negative for me. Both blinds are in the negative as well. QJs is up slightly, KQs is up nicely.

I need some help on how to play these hands. I cringe when I see QJo and KQo especially. Would you throw them away to a prior raise without any reads that the villain is loose? Or would you flat call and then c/f the flop?