I've been using PT to analyze opponents a good bit. The key is to get a good read on several players (watch all their hands when you have 800+ HH's on them), and note their stats. Then, see if you can spot others who have the same stats - they often (but not always) have the same leaks.

The key is to keep watching and learning, seeing what general conclusions seem valid. The most obvious ones are inane but often useful: facing a preflop standard raise from EP, I see a 8/2 super-nit in the stats. I look down to find A9s in the cutoff. I fold. But if the EP raiser is 80/35, I might rr.

Less obvious PT reads come with experience and just watching who's playing how and what their stats are.