By definition when you are “mixing it up” you’re not playing as well as you normally do. For example calling with AA isn’t the most profitable move normally. At the same time, if everyone folds to your reraise because they know you only do that when you have AA, KK, QQ, or AKs, your play will not be as profitable.

How much should I change my style to maximize my profit? … (Also, is mixing it up preflop enough, or should I also change my flop/turn/river play [I’m very aggressive as long as I have the odds])

I was thinking of playing 1 out of 20 of the hands opposite normal (call with AA, raise with KJo, and ignore position preflop in those hands) …

The other thought is to just ignore position some of the time preflop.

How much do I need to change my play to confuse players read to max my profit?

(When I finally really tightened up my preflop play, I helped my profit so much that I’m now resisting loosening up to mix up my play)

Thanks