We're in MP at NL10 with 22 and 100BB stack. TAGG UTG opens with a 4xBB raise (he also has 100BB stack). We call. Button LAGG with 50BB stack raises to 12BB, TAGG calls for 8BB more. Do we fold or call?

The 10x effective stack rule seems common. Let's assume that's our criteria. Effective stack is capped by LAGG's 42BB's left, and it takes 8BB to call. So with effective stack less than 6x the call, we fold.

I've seen posters say this is autofold, on FTR and elsewhere. That makes no sense to me. If both villain's seem likely to stack off with TP, 2 pr stuff, why aren't we calling here?

My view is this. Without the LAGG involved, we have 88BB's from the TAGG, or 11x our call. And there's dead money in the pot if we end up heads up against him. If we're last to act and can't get raised, shouldn't we call here? We have roughly the same likelihood of stacking the TAGG with or without the LAGG, so doesn't his stack and preflop bet money just make the call easier?

Some of the time, the TAGG gets chased out by the LAGG, but when he does he likely didn't have the cards to stack off to our set anyway. And the 22 plays OK postflop against the LAGG, though we have very little maneuvering room. And we'll almost surely get his stack when we flop the set.

This happens a lot at the micros, even in 4-way rr'd pots pre, with a short stack jumping in for fun. If we have 2 (or more) TAGG villains with big stacks in there already, shouldn't we be calling the rr?

Flame away.