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Dump 22-66 in early position. Maybe also middle position. That alone will prevent some "oversetting". Check your database and use filters to see where you loose money with your set mining (filter by position, by pair value, raised pots, limped pots, 3b pots, opponent's stats and position, etc) Find the leaks. The 22-66 in EP is a classic, that's why I mentioned it.
As for the hand, you can't get away from it. Maybe if the stacks were deeper and you have a very strong read that your opponent does not stack off with two pairs, or cannot have two pairs in this spot and does not stack off with TPTK.
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