If the original opener is completely positionally unaware (like an ATS of 20%), and we have an okay idea of when villain is likely to fold (to the 3b itself? to the cbet? etc.), then I could see this being a profitable squeeze due to the fact that the CO has a super wide range because he posted. It's not a great squeezing hands in terms of blockers (blocks folding range more than continuing range) and postflop playability, but hey, at least it hits top pair.

I'm really not a fan of flatting, especially since the PFR seems to have a solid cbet rate. We're not gonna take the pot down uncontested too much, and the times that 1) PFR's hand misses (with a strongish range), 2) we hit, 3) we're ahead of the fish but he hits something strong enough to commit a lot of money to doesn't seem all that common. So in other words, we're not winning the pot a lot, and the pots we do win aren't often going to be too big.