If the players are calling stations (therefore your advantage beign maximum profit on good hands) then playing more hands may allow you to make a greater profit, but to make sure that no one else beats you i would only play more hands when there are tight-players pre-flop.

If however you are with Lags who bet into your good hands i would just stay with my normal pre-flop strategy, because you would probably make a loss on haveing to fold many hands you do not make.