Actually fasin8ing, I'm mainly playing 25NL 6-max right now. I've spent plenty of time at the 50 and 100 levels where this is more important, but it applies at the 25 tables too - especially if you're at the right tables, with the right players. It's a question of feeling the ebb and flow of the game. You may only have half an hour to set up and properly exploit a table image, but I do it all the time. Obviously you wouldn't want to go out of your way to make multiple -EV plays as a setup, but I am not averse to making one quick head-scratcher if I feel the player on the receiving end - or (this is important) any other aware player at the table - might pay me off on something shortly thereafter. Conversely I'm also inclined to quickly build a very tight image (fold a lot of hands, fold a hand after raising with no c-bet, etc.) and then take advantage with a tricky bluff. Changing gears applies online, even at low stakes, but you have to understand who to use it against - and also that it has to be done more quickly, to take advantage of the table before the seats turn over.

Yes, you can do fine by playing good hands in a straightforward manner at 25 NL. But I guarantee you you can do better by throwing in at least a few surprises now and then - and you'll certainly be more prepared to move up to higher levels by practicing in when you feel the situation is right for it. Not every table, even at the lowest stakes, will be filled with loose/passive fish willing to dump their stacks on your sets and AA/KK, so sometimes you have to be more imaginative than that.