From my somewhat limited experience with HU I've noticed that the regs mainly fall into two categories, those that try to control the 3betting game and those that don't. I see a lot of regs who 3bet early and often in a match and then it kind of dies out as the game goes on and I respond the their aggression a couple times.

Gameflow is obviously super important so.... How important is it to establish a 3bet/4bet dynamic and to keep it going (both sngs and cash)?
How early?

I would think that in bloated pots the mistakes people can make are larger but is there a point where stack sizes are such that either the 4bet/5bet/6bet(**7bet/8bet/9bet) game is just getting too out of hand that you'd prefer to go back to small ball or is that even possible once stacks are deep?

(**I watched some pretty absurd sauce vs aejones hands with miech haha)