Larger sample size, the 4 mans are by far fishier. I played more than a few 25%+ ROI regs at around the $10 and $20 games. Still giant holes in their games obviously but the 4 mans are by far lighter. Variance can be a huge pain on the 4 mans tho. Had my best month ever in Jan with several big wins, Feb was barely profitable without any big mistakes. Long run the 4 mans are much better tho.