I think this applies a little less to microstakes. On the really really loose tables you find down there this will often get you into potentially expensive multi-ways vs stations who will call mid-pair+ down on you, and the c-bet costs you more...

depends really on the 3 or 4 villains to your left + limpers...

I think the fact that poker is like...almost always 'it depends', makes it the great game it is