I've never been a huge fan of any drama series unless you count Entourage. Typically they are too slow, too tense, and/or too gory. The Wire was decent. Sopranos seems pretty good but I haven't watched enough. Everything else has been really boring or just doesn't agree with me.
Entourage is by far my favorite show. I think a lot of shit that happens in Entourage doesn't really make sense, and while the acting gets hated on more than it deserves, it's not great (Drama>>>>E>Ari>>>Vince>>Turtle). The entertainment value is INSANE though; I've enjoyed each season of entourage significantly more than any season of any other show.
The other shows I watch or have watched on the reg, best to worst, are:
1. Family Guy- occasionally the jokes,plots,whole episodes even, get a facepalm, but this is the only show that makes me laugh super hard consistently. If you don't enjoy family guy you are a huge donk.
2. Curb Your Enthusiasm- dont try watching it with a chick, but this show rarely blows and usually has a fantastic ending
3. Arrested Development- really sweet show conceptually and generally very clever but overall a little bland and when a joke on AD sucks it often REALLY makes me cringe. like when they tried to make a joke that buster had attended high school for an extra 2 years without anyone noticing. that kind of fail makes me want to punch people
4. Weeds- fantastic for first 3 seasons. now i want to break the tv every time i watch it
5. South Park- Either it is a shadow of its former self or I've outgrown it, maybe some combination of the two...I would rate it far behind the others now but still worth catching every episode to see what happens. When I was in junior high-high school it was by far my favorite show.