Here are some of my subscriptions in the comedy category:

Singer/Songwriter... cool stuff
http://www.youtube.com/user/RoyZimmerman

Ex news reporter trying to get back into the news reporting business... Not always so funny, but she's very consistent and puts a lot of effort in it... also she's hot. I am not ashamed to say that I've gotten some important stuff from her channel first:
http://www.youtube.com/user/gnooze

Bible stories - might be offensive to certain religious types. I love this guy:
http://www.youtube.com/user/kalsolarUK

British comedian - might be extremely offensive to certain religious types. I'll link two of the videos that I think he absolutely nailed on the bottom... most of his later stuff suffers a little bit from the first hype:
http://www.youtube.com/user/patcondell
http://www.youtube.com/watch?v=V8PCecgWKeI
http://www.youtube.com/watch?v=Ly62n36nn0k