Since set under set and flush under flush have occured so many times in my current database of 220k hands I just chose to search such situations for one hand 33. There is no magical way to avoid coolers, everyone gets them.

http://www.pokerhand.nu/hand/4607
http://www.pokerhand.nu/hand/4608
http://www.pokerhand.nu/hand/4609
http://www.pokerhand.nu/hand/4610
http://www.pokerhand.nu/hand/4611

33 is still showing a profit.