Your thoughts on river bluffs??

ie. PFR AK EP at 6 max to 4xBB and get a caller in the blinds

he checks,you c/b 46T flop, he calls.

turns a 2, both check turn

river a Q, he checks river, you bet 2/3-3/4 pot

Im trying to rep AQ,KQ here. do you try any other line when considering bluffing? would you just fire 2nd barrel or make this play?

EDIT: my bluff had TPTK by mistake