Interesting post as always fnord.
I agree big money can be made from as rippy would term unorthodox play. My concern for this would be that this must become awfully swingy. You may call/raise with garbage or non-premium cards a lot and flop nothing/have to give up the pot but get paid when you flop a monster. So very up and down.
Secondly, in finding patterns in players you are essentially looking to bluff them when yo read they missed the flop. Again getting called on bluffs can be very costly and swingy, but also lucrative when it works.
I guess what im considering is that in order to win big you have to be prepared to lose big.