Getting back to the original post, I would modify my opening range somewhat, tightening up in early position and widening it in late position:

UTG: 99+, AQs+, AKo
UTG+1: 88+, AJs+, KQs, AQo+
MP1: 77+, AJs+, KQs+, AJo+
MP2: 66+, ATs+, KJs+, AJo+, KQo
MP3: 22+, A9s+, KTs+, QTs+, JTs-54s, ATo+, KJo+
CO: 22+, A2s+, K9s+, Q9s+, J8s+, T9s-54s, T8s-53s, A9o+, KTo+, QJo
Button: 22+, A2s+, K2s+, Q8s+, J7s+, T7s+, 96s+, 85s+, 75s+, 64s+, 53s+, A7o+, K9o+, Q9o+, J9o+, T9o

Or something along those lines. Keep in mind that this is an initial opening range only; I wouldn't necessarily be isolating limpers with all of these hands (except for the limp/call/fit-or-fold type). I base mid-late position raises a lot on how tight the players behind me are, especially the blinds. If the blinds never fold, my CO and Button range look more like my MP3 range. If the BB is like 6/6 and the players behind me are pretty straightforward, I might open my button range from MP3.

Also, I would be 3-betting not just for value against people with a PFR over 20, depending on our positions on the table of course, and I might cold call with a hand like JJ or TT in position and try to play postflop against my opponent's wide range.