The table dynamics of a given session can also drastically change back and forth between agg/passive and loose/tight. So it's probably just as wrong to *generally always play 22-55 UTG as it is to *generally always fold them. IMO if you feel you're just going to get outplayed postlfop then fold'em, but if that's the case there is certainly a better table out there to choose from. I'm not sure how profitable playing these hands in a higher stakes game would be, but because microstakes tables are usually either weak-tight or loose/passive, you'll either get lots of callers when you raise thus giving you great pot odds, or you'll get 1 or 2 callers who will fold to your c-bet 90% of the time, and won't let go of an overpair when you do happen to make your set.