It comes down to more than pot odds and thats where it gets tricky. You have to figure Implied odds, fold equity and +EV plays.

The biggest Implied odds and +EV plays for me have always been playing pocket pairs and hitting a fullhouse on the turn or river. Even though I don't have lots of outs to hit, I'll still call strong bets because when I do hit, (especially at my limits) the donks tend to do things like go allin at the river.