I appreciate you not wanting to be too villain specific, but this is SUCH a villain specific spot.

What are your assumptions here? What is his call 3b % vs 4b vs fold?

I find that players that fold most 3bets and that don't set hunt in 3b pots, are heavily Qx weighted (JQs/KQ/AQ and some stuff like 99-TT). Obviously vs these players betting and shutting down or c/c and c/f turn could be in order.

Some other players call all pairs, all suited hands etc. Vs. those players I'm happy firing twice here, because they are just generally cally to begin with and like putting us on AK.