I'm up late tonight, and at night there's rarely any FR tables going. I decided to try a little bit of 6max since there's always those games going

In 6 max i'm suppose to play a bit looser, but can someone enlighten me on a few of my concerns

1) What are button/CO opening ranges? And do ranges change when there is a limper in front of us?

2) My standard FR raise was 4x+1. Is this still an ideal opening raise?

3) Besides the aggressiveness and players/flop, what are the main differences between FR and 6max?