I just moved up to 50 and it is interesting. I have found that if you just use the same tactics as 25NL, but mix up your play more, you'll do well.

One of my favorite moves that seems to work at 50 when you have been aggressive preflop:

When you miss the flop, instead of going with the standard continuation bet, I like to occasionally just check out of position, and then do a check raise bluff. Works like a charm.