I find bet sizing to be a huge one. For instance someone might have 30% raise c-bet as a stat so you think they're FOS a lot, however if you've paid attention you would have noticed that they min-raise cbets a lot as a bluff, and std raise with 2P or better (or vice versa). If the first one, then you can just raise their minraises with air confidently, but if all you know is that they raise a lot, you might decide to play back by going to showdown with TPTK after they did a std raise because you hadnt picked up on the real read. Same thing when they have 100% donk bet, but they min donk with air and 2/3 psb donk with TP or better, etc.