I wasn't sure if you were referring to Limit or NL He, but just in case you wanted some limit advice I would say:

Just try and mix it up and play fast when you're going to enter a pot. Also, check-raising is one of the biggest element of short handed play. I'll check/raise anything SH. In many ways I like to play certain hands out of poistion short handed. Since you can almost always count on a bet from the button, you'll have way more oppourtunities to check/raise.

Play your draws fast. If you pick an OEr or a four-flush, bet it, raise it. I might even 3-bet a strong draw shorthanded on the flop just to pick up a free-card on the turn. And finally, overcards are really not that bad SH. Your opponents aren't going to be playing premium hands either. Bet to define your hand, see what happens.