Loose tables are where the money is at man. The nits aren't going to suck out on you, but you're gonna make a lot less money off of them than you do off of the crazy ones. Ofcourse you have to adjust your playstyle. Typically - and this is 6max - my VP$IP stays the same (around 30) on a looser table but my PFR drops from 15 (which I maintain on tighter tables) to 10.

But it's not just preflop. Your postflop game has to change too, that's even more important.