Lets say I have picked up a huge tell on a certain player who will raise 2x BB with cards such as AQ, AJs pretty consistently and (just to keep it simple) every time he has a KK or AA he will raise exactly 3.5x BB. Facing no resistance beyond cold calls on the flop and turn, he will bet the pot both times and say...maybe half the time or less will call an all-in re-raise on the river. This player reminds me alot of the average book-reading 25NL players I run into at times.

Anyways, assuming my read is dead on, would it ever be profitable to call his preflop raise with marginal hands, PPs, or less in the hopes of hitting the flop hard and de-stacking with at least a 2-pair vs his single overpair?

If the flop isnt favorable, fold. Draws are out the window with his pot bets.

Being able to see someone's hole cards (prettymuch) is a huge advantage, but so is having AA-KK heads-up.

Im guessing that this will not work out too well in the long run, as most marginal hands and PPs need several limpers to be profitable.

But still...