Every time you press a button at the poker table you'll need to think about villains' possible holdings.

Unless you have the stone cold nuts and are facing an all in, you'll probably have to think about what villain holds. If you don't then you're just pressing buttons and probably making alot of mistakes/missing out on value etc.

-What range of hands could he have called your turn bet with?
-From that range, which hands will likely fold on the river given the opponents tendencies?
-From the ranges you came up with, evaluate your expectation of betting, and if negative, consider your other options. (Hint: in many situations you will decide that a play is +EV, but another yields a higher overall expectation. When you're able to accurately estimate villains range and then estimate his likely action based on your action due to his tendencies, you can make alot of money)

Sorry if I'm missing something here in my advice...just wanted to point you in the right direction.