OK, if you want a slightly serious answer, playing short-stacked means that you won't be able to maximize value with your big hands, and you won't be able to push players out of hands when you need to thin the herd or want to take down the pot.
On the other hand, playing short-stacked decreases your opponents' implied odds and may get them to fold some drawing hands that they might otherwise play against you.
I happen to much prefer playing with a deep stack. But if you play good fundamental poker, at least at the microstakes it is probably possible to win using either approach. As you go up in stakes and skill level, the importance of aggression and the need to maximize the value of your big hands will make it very difficult for you to succeed with a small chip stack.
