yah adjustments at microstakes from the more perceptive opponents tend to be pretty big ones. easy to exploit (the reg) but harder for us to play vs the fish because reg sees us isoing a heap and starts 3betting us without any real awareness of his own range. i used to do this a lot and get absolutely crushed (edit: this was at 50nl 6m at a time when preflop aggro wars were all the rage. may not still hold true)