A little more info could be helpful here. What type of fish is the fish in the hand? Does he call post with A high, does he fold everything but the nuts, etc? Has the table been actively targeting the fish meaning there is a very limited amount of time to take his money? Does villain know any/all of this? Is villain willing/able to do anything with this info?

This should help us determine if villain in the hand is likely to have adjusted, and how he may have adjusted to the inclusion of the fish in the hand.

In a vacuum, this looks an awful lot like a Sklansky situation where you have flopped a monster with a redraw to a better hand, and a small chance that your opp can make a strong hand when you do improve, and then you overbet shove the nuts on the river.