My home game is often the same. Two or three people will call any pre-flop raise, and see most hands to the river. This is because they have no idea how to value their hand or how to calculate their odds of improving it. They must see the cards to find out the value of their hand.

They're almost always playing with 7 cards, while you are playing with 2, or maybe 5 cards. You know the value, odds of improving, size of the pot, etc, and can calculate the right move is to fold. Of course one of them will actually have a nice hand with 4 people taking it to the river.

Just tighten up, like the others already said. At my last game, I only played one hand (I folded it on the turn) until two people were eliminated. I had a shorter stack, but still had plenty of chips to get back in it.

The other tactic is to push a lot. TPTK? Push. It's the only way to isolate a player in these circumstances. And if you get a caller, he probably has TPLK.