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I'm always thinking "instinctually" about my opponent's hand. When scary flops come down and my opponent is betting into me, my job is usually not to think "globally" about his hand range, rather to think about his playing style (is he tight vs. loose, and passive vs. aggressive).
This author is advocating calculating a mathematical probability of success or failure based on your estimation of your opponent's play, and then your +/- EV is based on that global % (I'm getting a return of .50 on the dollar based on his entire hand range, so I should fold), rather than specific "instinct" (I have a 30% chance to suck him out if has the A, and I don't give him credit for it, and he'll go nuclear on the river if the club falls, so I call). These global EV's are distinct, because if you are at or above 50%, you continue playing. If you are ever very far below 50%, you fold outright.
This concept is distinct from pot odds/implied odds. If you can see your opponent's hand and know that you are behind and you get a cheap card (pot committed) you call because you are getting correct odds to stay.
If you are "globally" behind, you fold because the entire range of hands he is on puts you in a -EV situation.
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