Quote Originally Posted by spoonitnow
1. A lone Villain bets into you on the river and if you call you'll have a 25% chance to win. Should you call?
You still might call with slightly less than pot odds to do so in order to keep your opponent's bluffing frequency in line. Basically trading a small -EV mistake to protect our equity in future pots.

Actually trading small -EV mistakes to protect from bigger mistakes or to induce/exploit bigger mistakes is a pretty common big bet poker theme.