General 50 NL question

Currently I'm playing 10 NL (.5/.10) and im beating it at a little over 5 BB after about a 10,000 hand sample. If I keep this up for another 10,000 or so, I want to work my way up to 50 NL (.25/.50). I've seen a lotttt of players crush 10 NL and then go to 50 NL and can't win. My question is for anyone that has played both and can give me some of their thoughts on what major adjustments I must be ready to make in order to be profitable. Obviously, as I move up I expect players to be generally more competent and discipline, but I'm hoping for some more detailed explanations. Any feedback is greatly appreciated. Thanks!