Definitely a good spot to start flatting some stuff and c/r a ton of flops, 4b bluffing with blocker hands, and you can probably even get a bit tricky with some nut type hands though 4betting them does keep your 4b range more balanced.
also this
though clearly, 4bing AT every time is pretty bad.
But probably more than anything else, you might as well tighten up and just value town him every time.