Read dependent.
Some ppl just wont go away to the first c-bet, even if they have air (they like to float).
Some ppl will only stay if they hit or have a good draw.

Against the first, not a bad idea to 2barrel sometimes, or if you have outs and position, check behind on turn, hope to snap a bluff if you hit your outs.
Against the second, get out UI, they're not folding.

You need to know your opponents, without reads, just give up and move on to the next hand