You're chasing a 2-outer so the standard is basically check/fold OOP on a flop with overs that likely hit one of your opponents, although I'll c-bet HU and sometimes against two, depending on reads.

In position, c-bet the flop if it's checked to you, hover your foot over the brake if you get called but consider firing a second barrel if you get checked to again. A lot of players will auto-call a CO/BTN raise but give it up on the turn. Do it too much though - an aware player that hits the flop will start to slowplay you in those situations.

In general, set it or forget it is the best rule. Chasing 2-outers is a leak. C-betting too much is as well, so pick your spots carefully.