Easy to be narrow minded here, but we all put opponents to ranges and with practise learn the range they're willing to fold beyond the flop.

Ever noticed how often we raise a turned flush in position heads up, the opponent calls but is unwilling to call a river push? There is value here and in other spots crying out to be exploited. It doesn't work when we misjudge our opponents but the odd mistake makes for good metagame and we play our big hands roughly the same way.