Bluffing players with low VPIP and PFR stats?

How does this work for you?

I have learned over the past couple of days how important these two stats are, and when playing against someone with a VPIP/PFR of 33/20 that I shouldn't bluff too much but play them for value instead.

Of course when playing at tight tables making money can be more difficult, but I believe the logic behind these stats would be that someone with stats such as 17/5 or 22/14 would be easier to bluff against because they play tighter hands?