Just some thoughts at the micro level since I play the penny games allot on PS.

Typically I have found the average player rates in a SLAA range (by average VP$IP and aggressiveness factors), but a majority of players (by the number of players) are fish, calling stations, and rocks. I think overall I may run into a TAGG once a day on the average.

I have both PokerTracker and PokerAce and here's how I typically will find a somewhat decent bluff workable.

Using PokerAce of course to display player stats from PokerTracker, I look at three key pieces of information:

WTSD%: If they are under 35%, a bluff is liklely to work, but I only like to bluff only when I have at least middle pair with a decent kicker (I play TAGG or at the very worst SLAA depending on what gets dealt to me) and I'm in a later postion seeing no real strengths prior to me.

Folded to Continuations Bets >50% and at least 4 c-bet hands of data: Continuation bets are great to use as a bluff if they Fish or Rocks and have folded often to C-bets. This though may be classified not as a bluff (even if you have little to no hand), it can truly work most of the time. You don't have to risk very much either. I don't try this to calling stations though (see WTSD% above).

Auto-Rank Icon: Rocks, Fish, sLPP, & sLAP (passive post flop usually) players are good representations of people easily to bluff. If they are anything else, I WILL NOT BLUFF AT ALL! Any post-flop aggression player can lead to a disaster if called. Typicalling calling stations are not a great player to try this to though.

If I get a flush draw and a open ended stright draw, I will occassionally bluff even to the aggressive players I am playing and depending on how many people are in the pot (especially if I have the ace in my hand, or K if the Ace is on the board). Considering with this kind of hand I have a 60% chance of hitting the flush/str8. But I wont push unless i a late postion and nothing but small bets.