Having read none of the replies so far, here's my take.

I'm not really much of a guy for calling preflop with anything that isn't a pocket pair / suited connector. If the guy's a tight player (and especially if he has position on me like when I'm in the blinds, for instance), I'll fold my AKo. If he's tight pre-flop and postflop, and I'm confident that he doesn't have AA KK or QQ, I'll attempt to outplay him postflop by reraising hard here and then betting the flop. If I hit an A or K, good for me. If not, hopefully he doesn't have anything and I've scared him by reraising. Another good aspect of reraising is that if he does actually have me beat, he'll reraise me again more often than not, in which case I can comfortably lay my AKo down.

Against a LAG, I'll probably reraise, because I like to bust LAG's asses. But folding against them isn't a horrible option either. Calling is the worst thing you can do since if you catch, he's likely not to pay you off and if you don't catch, then you've lost your investment in the pot by calling.